Model of Allergic Bronchopulmonary Aspergillosis (ABPA) in Mice
Aspergillus is a common filamentus fungi and infection can result in three main types of bronchopulmonary aspergillosis; invasive aspergillosis, chronic aspergillosis, and allergic aspergillosis. Allergic
Mice are administered fungi suspended in agarose beads; a persistent fungal presence is observed for a minimum of 21 days after administration. Low level fungal presence and allergic responses are confirmed by measurable levels of BAL galactomannan and serum IgE respectively.
Image 1: Fungal Spores are embedded in agarose beads. Picture taken at magnification x 400
Image 2: Galactomannan (A biomarker of fungal infection, used in the clinic) is statistically significantly raised compared to the sham control group, confirming that there is an active fungal infection.
|Allergic aspergillosis in mice
|Efficacy of novel antifungals for ABPA
|Daily Bodyweights and Clinical Signs, serum IgE, fungal load, BAL differential cell counts, BAL cytokines and Pathology (H&E and PAS)
Study data generated by Labcorp Huntingdon Pharmacology.