Bronchoconstriction models for LABA, LAMA & MABAs
This model allows for the assessment of bronchoprotective effects of novel bronchodilators to agonist challenge (Methacholine and or Histamine) induced bronchoconstriction in the anaesthetised guinea-pig.
Formoterol demonstrated significant inhibition on resistance and compliance of airway induced by histamine and methacholine in anaesthetised guinea pig.
Formoterol also showed significant bronchoprotection against 5µg/kg histamine and methacholine challenge.
Dunkin Hartly Guinea Pig
|Screening and assessing the efficacy of new candidate LABA, LAMA and MABA's
|Invasive Lung Function (terminal) assessment of AHR (airway hyper responsiveness) using the Flexivent system
Study data generated by Labcorp Huntingdon Pharmacology.