Model of Invasive Aspergillosis in Immunocompromised Mice
Aspergillus is a common filamentus fungi and infection can result in three main types of bronchopulmonary aspergillosis; invasive aspergillosis, chronic aspergillosis, and allergic aspergillosis. Invasive aspergillosis affects severely immunocompromised patients and can lead to nearly 100 % mortality if left untreated.
Mice undergo an immunosuppression regimen and are administered fungi suspended in saline; model length can be manipulated by adjustment of the initial fungal load. At termination fungal load can be confirmed using the clinically relevant surrogate biomarker Galactomannan.
|Invasive aspergillosis in immunocompromised mice
|Efficacy of novel antifungals
|Daily Bodyweights and Clinical Signs, fungal load, BAL differential cell counts, BAL cytokines and Pathology (H&E and PAS).
Study data generated by Labcorp Huntingdon Pharmacology.